Dr Farah Wahida Suhaimi

 

Dr Farah Wahida Suhaimi   

DR. FARAH WAHIDA SUHAIMI

BSc (Hons) (Malaya), MSc, PhD (USM)

Contact Information:
E-mail: sfarahwahida@usm.my
Telephone: +604-653 2144
Fax: +604-656 8669
Address: Centre for Drug Research, Universiti Sains Malaysia, 11800 Penang

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Research

My field of research is neurobehaviour and cognition. I am particularly interested in the cognition that accompanies drug addiction. Brain areas and processes that underlie the drug addiction are overlapping extensively with those that underlie cognition, thus it would be beneficial to know if the treatment of the cognitive impairments is capable of ameliorating continuous drug use. Cognitive flexibilities including learning, memory and attention following drug addiction are evaluated using behavioural paradigms. The underlying neural mechanisms can be further determined by looking at the neurochemical release in specific brain regions using brain microdialysis in freely moving animals.

Current research project:

  • Assessment of the cognitive functions following mitragynine substitution in morphine-addicted rats.
  • Role of the cholinergic and glutamatergic systems in the cognitive functions following mitragynine substitution in morphine-addicted rats.

People

 

Publications

 SELECTED PUBLICATIONS (FROM 2010)

  1. Suhaimi, F.W., Yusoff, N.H., Hassan, R., Mansor, S.M., Navaratnam, V., Müller, C.P., Hassan, Z. (2016) Neurobiology of Kratom and its main alkaloid mitragynine. Brain Res Bull. 126, 29.
  2. Yusoff, N.H., Suhaimi, F.W., Vadivelu, R.K., Hassan, Z., Rümler, A., Rotter, A., Amato, D., Dringenberg, H.C., Mansor, S.M., Navaratnam, V., Müller, C.P. (2016) Abuse potential and adverse cognitive effects of mitragynine (kratom). Addict Biol. 21, 98.
  3. Hassan, Z., Muzaimi, M., Navaratnam, V., Yusoff, N.H., Suhaimi, F.W., Vadivelu, R., Vicknasingam, B.K., Amato, D., von Hörsten, S., Ismail, N.I., Jayabalan, N., Hazim, A.I., Mansor, S.M., Müller, C.P. (2013) From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction. Neurosci Biobehav Rev. 37, 138.
  4. Hassan, Z., Sattar, M.Z., Suhaimi, F.W., Yusoff, N.H., Abdulla, M.H., Yusof, A.P., Johns, E.J. (2013) Blunted endogenous GABA-mediated inhibition in the hypothalamic paraventricular nucleus of rats with streptozotocin-induced diabetes. Acta Neurol Belg. 113, 319.
  5. Suhaimi, F.W., Yusoff, N.H., Dewa, A., Yusof, A.P. (2010) Role of excitatory amino acid input in rostral ventrolateral medulla neurons in rats with obesity-induced hypertension. Acta Neurol Belg. 110, 57.

Published Abstracts

  1. Suhaimi, F., Hassan, Z., Navaratnam, V., Muller, C.P., Mansor, S.M. (2016) Effects of naloxone and bicuculline on acquisition of passive avoidance task in mitragynine-treated rats. Front. Cell. Neurosci. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00118.
  2. Hassan, Z., Suhaimi, F., Dringenberg, H.C., Muller, C.P. (2016) Impaired water maze learning and hippocampal long-term potentiation after mitragynine (Kratom) treatment in rats. Front. Cell. Neurosci. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00058.
  3. Suhaimi, F., Hassan, Z., Navaratnam, V., Müller C.P. (2012) Impairment of memory formation, consolidation and retrieval of inhibitory avoidance task in acute mitragynine-treated rats. Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference. doi: 10.3389/conf.fnhum.2012.208.00176.



Dr Juzaili Azizi

 

Dr Juzaili Azizi   

DR. JUZAILI AZIZI

BSc (Hons) (Malaya), MSc (USM), PhD (King’s College London)

Contact Information:
E-mail: juzaili.azizi@usm.my, juzaili.azizi@gmail.com
Telephone: +604-653 2159
Fax: +604-656 8669
Address: Centre for Drug Research, Universiti Sains Malaysia, 11800 Penang

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Research

My research interests are divided into two related fields namely blood-brain barrier (BBB) and the discovery of neuroprotective agent for the treatment of Parkinson’s disease (PD).

Blood-brain barrier:
Blood-brain barrier (BBB) is a vascular barrier formed at the level of brain capillary endothelial cells (BCEC). Expression of complex tight junctions impede the paracellular permeability of small charged molecules including nutrients and physiological ions such as glucose, amino acids and sodium. Expression of various carrier-mediated transporters and ion channels assist in two-way transport of these molecules (blood-to-brain vs brain-to-blood). Lipophilic compounds can easily permeate through the BCEC lipid bilayer, however, high expressions of efflux pumps at the BBB essentially extrude most of the lipophilic compounds en-route to the brain. The formation of BBB is the evolutionary strategy to maintain the optimum ionic concentration of brain interstitial fluid (ISF) for neuronal communications and signalling. Despite the importance of BBB in maintaining the optimum environment by avoiding rapid fluctuations of solutes content in brain ISF, it also impedes delivery of drug target for central nervous system (CNS) such as drugs for the treatment of Parkinson’s disease, brain tumour, pain and drug addiction. My research interest is therefore to manipulate various transport mechanisms at the BBB through chemical modification of drug or using nanocarrier to enhance brain penetration of potential CNS drug candidates. Brain permeability parameters like rate and extent of brain permeation of potential CNS drugs are obtained by in situ brain perfusion experiment in rodents which can also be used to obtain information on the mechanisms of brain uptake.

Parkinson’s disease:
Parkinson’s disease (PD) is the second most frequent neurodegenerative disease in the world. As the population of older people increase due to improvement of living standard, so does the population of PD. Current primary treatment with levodopa (L-DOPA) focusses on improvement of symptomatic PD without delaying dopaminergic neuron cell death in the basal ganglia. Treatment with L-DOPA comes with side effects with the most prominent one is L-DOPA induced dyskinesia (LID). L-DOPA will also not be effective when most of dopaminergic neurons have loss. Currently, there are no single effective neuroprotective agent for PD in the clinic to delay or stop dopaminergic neurons death in the basal ganglia. Therefore, my research interest is to screen the potential neuroprotective compounds in in vitro and in vivo models of PD. Currently available are chemically synthesised β-carboline derivatives and isolated flavonoids from Pteridophytes (edible fern).

People

 

Publications

SELECTED PUBLICATIONS (FROM 2010)

  1. Joseph, A., Contini, C., Cecchin, D., Nyberg, S., Ruiz-Perez, L., Gaitzsch, J., Fullstone, G., Tian, X., Azizi, J., Preston, J., Volpe, G., Battaglia, G. (2017) Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing. Sci Adv. 3, e1700362Sci Adv. 3, e1700362.
  2. Azizi, J., Ismail, S., Mansor, S.M. (2013) Mitragyna speciosa Korth leaves extracts induced the CYP450 catalyzed aminopyrine-N-demethylase (APND) and UDP-glucuronosyl transferase (UGT) activities in male Sprague-Dawley rat livers. Drug Metabol Drug Interact. 28, 95.
  3. Azizi, J., Ismail, S., Mordi, M.N., Ramanathan, S., Said, M.I., Mansor, S.M. (2010) In vitro and in vivo effects of three different Mitragyna speciosa korth leaf extracts on phase II drug metabolizing enzymes--glutathione transferases (GSTs). Molecules. 15, 432.
  4. Hanapi, N. A., Azizi, J., Ismail, S., Mansor, S. M. (2010) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro. International Journal of Pharmacology, 6, 494.

Published Abstracts

  1. Ismail, S., Hanapi, N.A., Azizi, J., Mansor, S.M., Mahmud, R. (2010) Inhibition of human cytochrome P450 isoforms by Mitragyna speciosa extracts. Drug Metabolism Reviews 42, 144. 9th International Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX).



Dr. Norsyifa Harun

Dr Norsyifa Harun

DR. NORSYIFA HARUN
BSc (Hons) (Adelaide), PhD (USM)

Contact Information:
E-mail: norsyifaharun@usm.my
Telephone: +604-653 5255
Fax: +604-656 8669
Address: Centre for Drug Research, Universiti Sains Malaysia,
11800 Penang
Google Scholar


Research

My research interests are focused in the field of behavioural pharmacology. The studies utilize different animal models to study the effects of drugs on behaviour and also to determine mechanisms of actions of drugs. One of my primary research interest is the behavioural pharmacology of psychoactive compound mitragynine and its 7-hydroxymitragynine derivative to understand kratom abuse and addiction. One of the most important animal model known as drug discrimination is developed to assess the effects of drugs that parallel the subjective effects experienced in humans. Other animal model that is also developed at CDR includes intravenous drug self-administration. This model is used to assess the reinforcing effects of drugs and thus provides valuable information about human drug-taking behaviour.

Current Research Project:

  • Evaluation of withdrawal effects of mitragynine on scheduled-controlled behaviour and drug discrimination procedure in rats
  • The assessment of mitragynine and its 7-hydroxymitragynine derivative to serve as positive reinforcers in rats
  • Oral self-administration of kratom juice in rats to provide clear face-validity to kratom consumption in humans

Publications

SELECTED PUBLICATIONS (FROM 2010)

  1. Harun, N., Hassan, Z., Navaratnam, V., Mansor, S.M., Shoaib, M. (2015) Discriminative stimulus properties of mitragynine (Kratom) in rats. Psychopharmacology (Berl), 232 (13), 2227-2238.
  2. Robertson, S.A., Harun, N., Moldenhaur, L.M. (2011) Repeated seminal fluid exposure expands regulatory T cell populations in mice. Biology of Reproduction, 85: 74

 Published Abstract

  1. Harun, N., Hassan, Z., Navaratnam, V., Mansor, S.M., Shoaib, M. (2014) Discriminative stimulus properties of mitragynine, an alkaloid derived from leaves Mitragyna speciosa (Kratom). Journal of Psychopharmacology, 28 (8), A88.
  2. Shoaib, M. &Harun, N. (2012). Impact of sub-chronic ketamine exposure on the reinforcing effects of nicotine in rats: implications for self-medication in schizophrenia. Society of Neuroscience (SFN).
  3. Moldenhauer, L.M, Guerin, L.R, Harun, N., Hayball J.D., Robertson, S.A. (2011). Role of T cell-mediated immune responses in healthy and complicated pregnancy. Frontiers in Reproductive Biotechnology.



Dr. Darshan Singh Mahinder Singh

Dr Darshan   

DR. DARSHAN SINGH MAHINDER SINGH
Bachelor of Commerce (Deakin University, Australia), Master of Public Administration (USM), PhD (USM)

Contact Information:
E-mail: darshan@usm.my
Telephone: +604-653 6029
Fax: +604-656 8669
Address: Centre for Drug Research, Universiti Sains Malaysia, 11800 Penang
Google Scholar


Research

My key research area is on the abuse of psychotropic substances, addiction treatment and harm-reduction prevention.  My research interests include studying the long-term effects of ketum (Mitragyna speciosa) use in ketum users, identifying methadone treatment barriers, assessing risky injection and sexual behaviours of amphetamine-type-stimulants (amphetamine/methamphetamine) users, determining treatment needs of female-drug users, as well as evaluating the effectiveness of evidence-based harm reduction programs such as methadone therapy and needle-exchange program.  I also conduct research to monitor the current trends and health and social issues related to the drug abuse situation in the country.  My research basically involves out-of-treatment heroin, ATS, ketamine, poly-drug users and people who used New Psychoactive Substances (NPS).  I am also proactively involved in University-Community engagement programs targeting communities plagued with substance abuse problems.  My research aims to determine the social, health and economic impact of drug use on the quality-of-life of drug users.

Current Research Project:

  • Risky sexual and criminal behaviours of amphetamine type stimulant (ATS) users in Penang
  • Barriers to treatment compliance among patients in Methadone Maintenance Treatment (MMT) Program in Malaysia
  • Opiate treatment barriers and risky sexual behaviours of female drug users (FDUs) in Malaysia
  • Risky behaviours and psychological problems in pil kuda (ATS) users in Kelantan
  • Behavioural characteristics and cognitive evaluation in ketum (Mitragyna speciosa) users in Malaysia

People

Current PhD student (as main supervisor)

  • Nadiah Mohd Saref
  • Norazlin Mohd Saref

Current Masters students (as main supervisor)

  • Charles George Gajim
  • Harinderan A/L Krishnan
  • Normazaini Mohd Noor
  • Ruzmayuddin Mamat

Publications

SELECTED PUBLICATIONS (FROM 2010)

  1. Leong Bin Abdullah M.F.I, Singh, D., Vicknasingam, B.K. 2018. Case report of recreational Lysergic-Aciddiethylamide (LSD) use In Malaysia. ASEAN Journal of Psychiatry, 19(1), 21-23.
  2. Singh, D., Narayanan, S., Müller, C.P., Swogger, M.T., Rahim, A.A., Leong Bin Abdullah M.F.I., Vicknasingam, B.K. (2018) Severity of kratom (Mitragyna speciosa Korth.) psychological withdrawal symptoms. J Psychoactive Drugs. 2018 Aug 28:1-6. doi: 10.1080/02791072.2018.1511879. [Epub ahead of print]
  3. Vicknasingam, B., Narayanan, S., Singh, D., Chawarski, M. (2018) Decriminalization of drug use. Curr Opin Psychiatry. 2018 May 8. doi: 10.1097/YCO.0000000000000429. [Epub ahead of print]
  4. Singh, D., Murugaiyah, V., Hamid, S.B.S., Kasinather, V., Chan, M.S.A., Ho, E.T.W., Grundmann, O., Chear, N.J.Y., Mansor, S.M. (2018) Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users. J Ethnopharmacol., 221, 30-36
  5. Singh, D., Narayanan, S., Vicknasingam, B.K., Prozialeck, W.C., Ramanathan, S., Zainal, H., Harun, S.N. (2018) Severity of Pain and Sleep Problems during Kratom (Mitragyna speciosa Korth.) Cessation among regular kratom users. J Psychoactive Drugs., 20, 1.
  6. Singh, D., Müller, C.P., Murugaiyah, V., Hamid, S.B.S., Vicknasingam, B.K., Avery, B., Chear, N.J.Y., Mansor, S.M. (2018) Evaluating the hematological and clinical-chemistry parameters of kratom (Mitragyna speciosa) users in Malaysia. J Ethnopharmacol., 214, 197.
  7. Hassan, Z., Bosch, O.G., Singh, D., Narayanan, S., Kasinather, B.V., Seifritz, E., Kornhuber, J., Quednow, B.B., Müller, C.P. (2017) Novel Psychoactive Substances-Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs. Front Psychiatry, 8, 152.
  8. Singh, D., Narayanan, S., Vicknasingam, B., Corazza, O., Santacroce, R., Roman-Urrestarazu, A. (2017) Changing trends in the use of kratom (Mitragyna speciosa) in Southeast Asia. Hum Psychopharmacol., doi: 10.1002/hup.2582. 
  9. Singh, D., Narayanan, S., Vicknasingam, B. (2016) Traditional and non-traditional uses of Mitragynine (Kratom): A survey of the literature. Brain Res Bull., 126 (Pt 1), 41-46.
  10. Suppiah, B., Vicknasingam, B., Singh, D., Narayanan, S. (2016) Erectile dysfunction among people who use ketamine and poly-drugs. J Psychoactive Drugs, 48 (2), 86-92.
  11. Cinosi, E., Martinotti, G., Singh, D., Demetrovics, Z.,  Roman-Urrestarazu, A., Bersani, F.S., Vicknasingam, B., Piazzon, G., Li, J.H., Yu, W.J., Kapitány-Fövény, M., Farkas, J., Di Giannantonio, M., Corazza, O. (2015) Following “the roots” of Kratom (Mitragyna speciosa): The evolution of an enhancer from a traditional use to increase work and productivity in South-East Asia to a recreational psychoactive drug in Western Countries. BioMed Res Int., Article ID 968786.
  12. Vicknasingam, B., Narayanan, S., Singh, D. (2015) The rise of groin injection among opiate drug users in Malaysia. International Journal of Prevention and Treatment of Substance Use Disorders, 1 (3), 142-152.
  13. Vicknasingam, B., Dazali., M.N., Singh, D., Schottenfeld, R.S., Chawarski, M.C. (2015) Buprenorphine/naloxone treatment practices in Malaysia: Results of national survey of physician and patients. Drug Alcohol Depend., 152, 164-169.
  14. Singh, D., Müller, C.P., Vicknasingam B.K., Mansor, S.M. (2015) Social-functioning of Kratom (Mitragyna speciosa) users in Malaysia. J Psychoactive Drugs, 47 (2), 125-131.
  15. Singh, D., Müller C.P., Vicknasingam B.K. (2014) Kratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users. Drug Alcohol Depend., 139, 132-137.
  16. Singh, D., Chawarski, M.C., Schottenfeld, R., Vicknasingam, B. (2013) Substance abuse and HIV situation in Malaysia. J Food Drug Anal., 21 (4), S46-51.

Selected Reports (from 2010)

  1. Most-at-risk children in central Kuala Lumpur; What do they think and know about risk? Report for UNICEF Malaysia (2013) Assisted principal investigator in data collection and data analysis.
  2. A study of most-at-risk women in urban Kuala Lumpur. Report for UNICEF Malaysia (2013) Assisted principal investigator in data collection and data analysis.
  3. Prepared report for ‘Kertas Cadangan Bagi Membangunkan Model Holistik Terbaik Program Pendidikan Inklusif Untuk Malaysia’. Report prepared for Ministry of Education (2013).
  4. The informal use of Kratom among the local masses in the northern states of Malaysia (2010) Assisted principal investigator in data collection and drafting manuscript for publication.

Published Abstract

  1. Cinosi, E., Simonato, P., Singh, D., Bersani, F.S., Piazzon, G., Lupi, M., Marini, S., Kapitány-Fövény, M., Farkas, J., Demetrovics, Z., Roman-Urrestarazu, A., Vicknasingam, B., Li, J.H., Yu, W.J., Santacroce, R., Acciavatti, T., Martinotti, G., Di Giannantonio, M., Corazza, O. (2016) A comprehensive overview on Kratom. European Psychiatry, 33, S354-S355.



Associate Prof. Dr. Zurina Hassan

Dr Zurina 

ASSOCIATE PROF. DR. ZURINA HASSAN
BSc (Hons) (UK), MSc (USM), PhD (USM)

Contact Information:
E-mail: zurina_hassan@usm.my
Telephone: +604-653 2726
Fax: +604-656 8669
Address: Centre for Drug Research, Universiti Sains Malaysia,
11800 Penang
Google Scholar

 
   

 


Research

 The behavioural neuroscience was founded in October 2010 at the Centre for Drug Research (CDR), Universiti Sains Malaysia, Penang, Malaysia.  We were given the mandate to establish a new behavioural neuroscience lab at this centre.  We are the pioneer in this institution and embarked on a new niche area of research focusing on Behaviour Research in Addiction.  We emphasize on behaviour neuroscience and striving to be a reference centre for those who are planning to participate in behaviour neuroscience in their research.  Our concern is to understand the neural mechanisms of motivation, learning and memory especially in drug addiction and neurodegenerative disease.  We have developed the Electrophysiology Lab focusing on brain activity (EEG) and in vivo synaptic plasticity.  A technique known as in vivo microdialysis is developed at CDR to measure the dynamic changes on extracellular levels of neurotransmitters in the specific brain sites.  Using this method, information on the correlations between the behavioural effects and neurochemical events could be possibly addressed.  Examination on the involvement of systemic opioid, GABA, noradrenergic, dopaminergic and serotonergic system on these addictive behaviours enable comprehensive understanding of how brain mechanisms regulate these complex behaviours.

Current Research Projects:

  • Role of dopamine and its reflection in spectral frequencies of EEG in freely moving addictive rats
  • Behavioural research in addiction
  • Effects of psychoactive drugs on changes in spontaneous electroencephalographic (EEG) and behavioral activities in addictive animal models
  • Neural mechanism of mitragynine (a major indole alkaloid of Mitragyna speciosa) rewarding properties and neurochemical events in several discrete brain areas: potential treatment of opiate addiction
  • Evaluation of addiction severity and withdrawal effect in mitragynine treated rats
  • Neuroplasticity and role of cholinergic system in cognitive behaviour
  • Brain activity (EEG) and synaptic plasticity in chronic cerebral ischemia model
  • Neuroprotective effects of standardized Clitorea ternatea root extract for the treatment of memory disorders and improving cognitive behaviour in chronic cerebral ischemia model
  • Evaluations of neuroprotective activity of standardized ethanolic Orthosiphon stamineus extract to ameliorate cognitive alterations in Alzheimer's disease

People

Current PhD students (as main supervisor)

  • Mohamad Azmeer Effendy Md Salim
  • Rahimah Hassan
  • Nurul Aqmar Mohamad Nor Hazalin
  • Thenmoly A/P K Damodaran
  • Nurul Hasnida Mohammad Yusof

Current MSc student (as main supervisor)

  • Tiang Ning

Publications

SELECTED PUBLICATIONS (FROM 2010)

  1. Damodaran, T., Tan, B.W.L., Liao, P., Ramanathan, S., Keat, L.G., Hassan, Z. (2018) Clitoria ternatea L. root extract ameliorated the cognitive and hippocampal long-term potentiation deficits induced by chronic cerebral hypoperfusion in the rat. J Ethnopharmacol., 224, 381-390.
  2. Yusoff, N.H.M., Mansor, S.M., Müller, C.P., Hassan, Z. (2018) Baclofen blocks the acquisition and expression of mitragynine-induced conditioned place preference in rats. Behav Brain Res., 345, 65.
  3. Hassan, Z., Bosch, O.G., Singh, D., Narayanan, S., Kasinather, B.V., Seifritz, E., Kornhuber, J., Quednow, B.B., Müller, C.P. (2017) Novel Psychoactive Substances-Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs. Front Psychiatry, 8, 152.
  4. Yusoff, N.H.M., Mansor, S.M., Müller, C.P., Hassan, Z. (2017) Opioid receptors mediate the acquisition, but not the expression of mitragynine-induced conditioned place preference in rats. Behav Brain Res., 332, 1-6.
  5. Müller, C.P., Hassan, Z. (2016) The evaluation of new psychoactive drugs. Brain Res Bull., 126 (Pt 1), 1-2.
  6. Suhaimi, F.W., Yusoff, N.H., Hassan, R., Mansor, S.M., Navaratnam, V., Müller, C.P., Hassan, Z.  (2016) Neurobiology of Kratom and its main alkaloid mitragynine. Brain Res Bull., 126 (Pt 1), 29-40.
  7. Yusoff, N.H., Suhaimi, F.W., Vadivelu, R.K. , Hassan, Z., Rümler, A., Rotter, A., Amato, D., Dringenberg, H.C., Mansor, S.M., Navaratnam, V., Müller, C.P. (2016). Abuse potential and adverse cognitive effects of mitragynine (kratom). Addiction Biology, 21 (1), 98-110.
  8. Mustaffa, F., Hassan, Z., Asmawi, M.Z. (2016). Cinnamomum iners leaves as an alternative therapy for diabetes. Asian Journal of Biochemistry, 11 (1), 44-52.
  9. Mustaffa, F., Hassan, Z., Asmawi, M.Z. (2016). Antioxidant activity of Cinnamomum iners leaves standardized extract. Asian Journal of Biochemistry, 11 (2), 90-96.
  10. Harun, N., Hassan, Z., Navaratnam, V., Mansor, S.M., Shoaib, M. (2015) Discriminative stimulus properties of mitragynine (Kratom) in rats. Psychopharmacology (Berl), 232 (13), 2227-2238.
  11. Harun, N., Hassan, Z., Navaratnam, V., Mansor, S.M., Shoaib, M. (2014) Discriminative stimulus properties of mitragynine, an alkaloid derived from leaves Mitragyna speciosa (Kratom). Journal of Psychopharmacology, 28 (8), A88.
  12. Mustaffa, F., Hassan, Z., Yusof, N.A., Razak, K.N.A., Asmawi, M.Z. (2014) Bioassay-guided antidiabetic mechanisms of Cinnamomum iners leaves extract. World Journal of Pharmaceutical Research, 3 (6), 1924-1935.
  13. Damodaran, T., Hassan, Z., Navaratnam, V., Muzaimi, M., Ng, G., Müller, C.P., Liao, P., Dringenberg H.C. (2014) Time course of motor and cognitive functions after chronic cerebral ischemia in rats. Behav Brain Res., 275, 252-258.
  14. Kura, A.U., Cheah, P.S., Hussein, M.Z., Hassan, Z., Tengku Azmi, T.I., Hussein, N.F., Fakurazi, S. (2014) Toxicity evaluation of zinc aluminium levodopa nanocomposite via oral route in repeated dose study. Nanoscale Res Lett., 9 (1), 261.
  15. Mustaffa, F., Hassan, Z., Yusof, N.A., Abdul Razak, K.N., Asmawi, M.Z.  (2014) Antidiabetic and antihyperlipidemic potential of standardized extract, fraction and subfraction of Cinnamomum iners Leaves. International Journal of Pharmacy and Pharmaceutical Sciences, 6 (5), 220-225.
  16. Mustaffa, F., Hassan, Z., Yusof, N.A., Abdul Razak, K.N., Asmawi, M.Z.  (2014) Antidiabetic mechanism of standardized extract, fraction and subfraction of Cinnamomum iners leaves. Int. J. Pharm. Sci. Rev. Res., 26 (2), 209-214.
  17. Manshor, N.M., Dewa, A., Asmawi, M.Z., Ismail, Z., Razali, N., Hassan, Z. (2013) Vascular reactivity concerning Orthosiphon stamineus Benth-mediated antihypertensive in aortic rings of spontaneous hypertensive rats. International Journal of Vascular Medicine, Article ID 456852.
  18. Hassan, Z., Sattar, M.Z., Suhaimi, F.W., Yusoff, N.H., Abdulla, M.H., Yusof, A.P., Johns, E.J. (2013) Blunted endogenous GABA-mediated inhibition in the hypothalamic paraventricular nucleus of rats with streptozotocin-induced diabetes. Acta Neurol Belg., 113 (3), 319-325.
  19. Razali, N., Dewa, A., Asmawi, M.Z., Ismail, Z., Mansor, N.M., Hassan, Z. (2013) Vascular reactivity on aortic rings of spontaneously hypertensive rats treated with methanolic and water extracts of Ficus deltoidea. J Exp Integr Med., 3 (2), 93-102.
  20. Hassan, Z., Muzaimi, M., Navaratnam, V., Yusoff, N.H., Suhaimi, F.W., Vadivelu, R., Vicknasingam, B.K., Amato, D., von HÖrsten, S., Ismail, N.I., Jayabalan, N., Hazim, A.I., Mansor, S.M., Müller, C.P. (2013) From kratom to mitragynine and its derivatives: physiological and behavioral effects related to use, abuse, and addiction. Neurosci Biobehav Rev., 37 (2), 138-151.
  21. Hassan, Z., Dewa, A., Asmawi, M.Z., Sattar, M.Z. (2011) Assessment of vascular reactivity at different time-course on STZ-induced diabetic rats. J Exp Integr Med., 1 (3), 175-183.
  22. Hassan, Z., Yam, M.F., Ahmad, M., Yusof, A.P. (2010) Antidiabetic properties and mechanism of action of Gynura procumbens water extract in streptozotocin-induced diabetic rat. Molecules, 15 (12), 9008-9023.

Published Abstract

  1. Nur Hidayah Kaz Abdul Aziz, Norhalida Hashim, Zurina Hassan (2017) Differential effects of parity, stress and fluoxetine treatment on locomotor activity and swimming behavior in rats. World Academy of Science, Engineering and Technology International Journal of Pharmacological and Pharmaceutical Sciences, 11(12), urn:dai:10.1999/1307-6892/80531.
  2. Nor Fasihah Azam, Zurina Hassan, Hans C. Dringenberg (2014) The effect of permanent occlusion of common carotid arteries on electroencephalogram (EEG) in rat’s brain. Archives of Pharmacy Practice, 5 (Supplement 1), S9.
  3. Hasnida, N., Yusoff, M., Hassan, Z., Visweswaran, N., Müller C.P. (2013) Simultaneous monitoring of conditioned place preference and locomotor sensitization in mitragynine-treated rats. Behavioural Pharmacology, 24 (e-Supplement Abstract of the 15th Biennial Meeting of the European behavioural Pharmacology Society, La Rochelle, September 6-9, 2013) e58, October 2013.
  4. Mohammad Yusoff, N., Hassan, Z., Navaratnam, V., Müller, C.P. (2012) Effects of acute mitragynine exposure on the establishment of conditioned place preference and locomotor activity. Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference. doi: 10.3389/conf.fnhum.2012.208.00118.
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