Professor Dr. Sharif Mahsufi Mansor

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PROFESSOR DR. SHARIF MAHSUFI MANSOR
B Pharm (Hons), MSc (Pharm) (USM), PhD (Liverpool)

Contact Information:
E-mail: smahsufi@usm.my
Telephone: +604-653 3273
Fax: +604-656 8669
Address: Centre for Drug Research, Universiti Sains Malaysia,
11800 Penang

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Research

Current research focuses on drug development and preclinical studies of potential compounds from natural, semi-synthetic, for the treatment of addiction and pain.  Mitragynine, the main alkaloid from Mitragyna speciosa, and its analogue, is one of the series of compounds which are currently being evaluated under this research programme.  This potential product will be a lead compound for the development of new types of analgesics having structures different from that of morphine, and will also be lead compound for the development of new substitution therapies having structures different from that of methadone or buprenorphine.  Refinement may be necessary to optimize the lead compound to produce a potential drug candidate for clinical trial.  The potency, efficacy and safety of a drug candidate depend on the chemical and structural specificity of drug-target interaction.  The preclinical and development process will focus on pharmacokinetic (action of the body on the drug), pharmacodynamic (action of the drug on the target) and toxicity studies.  Data from these studies will enable dose and dosing regimens to be finalized for clinical trials. 

Current Research Project:

  • Addictive liability and cognitive behavior of mitragynine and its analogs in animal models
  • Design and synthesis of chemical library focused on opiate and anticancer activities
  • Development of medical treatments for co-occuring opioid (heroin or morphine) and amphetamine-type stimulants (ATS) dependence (COATS) (co-researcher)
  • Development of a new mitragynine formulation for application in analgesic study (co-researcher)
  • Glutathione-S-transferases as targets for novel antimalarial compounds (co-researcher)
  • Behavioural research in addiction (co-researcher)
  • Neural mechanism of mitragynine (a major indole alkaloid of Mitragyna speciosa) rewarding properties and neurochemical events in several discrete brain areas: potential treatment of opiate addiction (co-researcher)
  • Neuroprotective effects of standardized Clitorea ternatea root extract for the treatment of memory disorders and improving cognitive behaviour in chronic cerebral ischemia model (co-researcher)

People

Current PhD students (as main supervisor)

  • Kamilla A/P Linggam
  • Nur Azzalia Kamaruzaman

Publications

SELECTED PUBLICATIONS (FROM 2010)

  1. Yusoff, N.H.M., Mansor, S.M., Müller, C.P., Hassan, Z. (2017) Opioid receptors mediate the acquisition, but not the expression of mitragynine-induced conditioned place preference in rats. Behav Brain Res., 332, 1-6.
  2. Meesala, R., Arshad, A.S.M., Mordi, M.N., Mansor, S.M. (2016) Iodine-catalyzed one-pot decarboxylative aromatization of tetrahydro-β-carbolines. Tetrahedron, 72 (52), 8537-8541.
  3. Venugopalan, S.K., Shanmugarajan, T.S., Navaratnam, V., Mansor, S.M., Ramanathan, S. (2016) Dexamethasone provoked mitochondrial perturbations in thymus: Possible role of N-acetylglucosamine in restoration of mitochondrial function. Biomed Pharmacother., 83, 1485-1492.
  4. Al-Qattan, M.N., Mordi, M.N., Mansor, S.M. (2016) Assembly of ligands interaction models for glutathione-S-transferases from Plasmodium falciparum, human and mouse using enzyme kinetics and molecular docking. Comput Biol Chem., 64, 237-249.
  5. Amat Sain, A., Amanah, A., Zahari, Z., Mohd Salim, R.J., Mansor, S.M., Adenan, M.I. (2016) (+)-Spectaline, a piperidine alkaloid from Senna spectabilis DC. effective in reducing the in vitro infection of Leishmania major. International Journal of Pharmacology, Phytochemistry and Ethnomedicine, 3, 1-8.
  6. Ismail, N.I., Jayabalan, N., Mansor, S.M., Müller, C.P., Muzaimi, M. (2016) Chronic mitragynine (kratom) enhances punishment resistance in natural reward seeking and impairs place learning in mice. Addict Biol., doi: 10.1111/adb.12385.
  7. Suhaimi, F.W., Yusoff, N.H., Hassan, R., Mansor, S.M., Navaratnam, V., Müller, C.P., Hassan, Z. (2016) Neurobiology of Kratom and its main alkaloid mitragynine. Brain Res Bull., 126 (Pt 1), 29-40.
  8. Yusoff, N.H., Suhaimi, F.W., Vadivelu, R.K., Hassan, Z., Rümler, A., Rotter, A., Amato, D., Dringenberg, H.C., Mansor, S.M., Navaratnam, V., Müller, C.P. (2016) Abuse potential and adverse cognitive effects of mitragynine (kratom). Addict Biol., 21 (1), 98-110.
  9. Ilmie, M.U., Jaafar, H., Mansor, S.M., Abdullah, J.M. (2015) Subchronic toxicity study of standardized methanolic extract of Mitragyna speciosa  Korth in Sprague dawley rats. Front Neurosci., 9, 189.
  10. Ilmie, M.U., Mansor, S.M., Abdullah, J.M. (2015).  Behavioural and electrophysiological evidence of impaired learning and memory in male Sprague dawley rats following subchronic exposure to standardised methanolic extract of Mitragyna speciosa Korth. Malays J Med Sci., 22 (Spec Issue), 45-51.
  11. Singh, D., Müller, C.P., Vicknasingam, B.K., Mansor, S.M. (2015) Social functioning of Kratom (Mitragyna speciosa) users in Malaysia. J Psychoactive Drugs, 47 (2), 125-131.
  12. Goh, T.B., Mordi, M.N., Mas Haris, M.R., Mansor, S.M. (2015). NMR structural assignments for four new 6-methoxy-tetrahydro-β-carboline derivatives. Magn Reson Chem., 53 (10), 857-859.
  13. Goh, T.B., Mordi, M.N., Mansor, S.M. (2015) Mass spectromentry (LC-MS-MS) as a tool in the Maillard reaction optimisation and characterisation of new 6-methoxy-tetrahydro-β-carboline derivatives. Sains Malaysiana, 44 (1), 127-137.
  14. Danladi, S., Wan-Azemin, A., Sani, Y.N., Mohd, K.S., Mahadeva Rao, U.S., Mansor, S.M., Dharmaraj, S. (2015) Phytochemical screening, antioxidant potential and cytotoxic activity of Melastoma malabathricum linn. from different locations. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (7), 408-413.
  15. Danladi, S., Wan-Azemin, A., Sani, Y.N., Mohd, K.S., Mahadeva Rao, U.S., Mansor, S.M., Dharmaraj, S. (2015) Phytochemical screening, total phenolic and total flavonoid content, and antioxidant activity of different parts of Melastoma malabathricum. Jurnal Teknologi, 77 (2), 63-68.
  16. Ramanathan, S., Parthasarathy, S., Murugaiyah, V., Tan, S.C., Mansor, S.M. (2015) Understanding the physicochemical properties of mitragynine, principal alkaloid of Mitragyna speciosa, for preclinical evaluation. Molecules, 20 (3), 4915-4927.
  17. Goh,T.B., Koh, R.Y., Yam, M.F., Mordi, M.N., Mansor, S.M. (2015) 5- Methoxytrypthamine reacts with natural food flavour to produce 6-methoxy tetrahydro-β-carbolines: in vitro investigation of their antioxidant and cytotocity properties. Food Chem., 183, 208-216.
  18. Harun, N., Hassan, Z., Navaratnam, V., Mansor, S.M., Shoaib, M. (2015) Discriminative stimulus properties of mitragynine (kratom) in rats. Psychopharmacology (Berl), 232 (13), 2227-2238.
  19. Ramu Meesala, Ahmad Saifuddin Mohamad Arshad, Mohd Nizam Mordi, Sharif Mahsufi Mansor. (2014) A facile synthesis of (carbazolyl) formamidines. Tetrahedron Letters, 55 (51), 7023-7025.
  20. Yusoff, N.H., Suhaimi, F.W., Vadivelu, R.K., Hassan, Z., Rümler, A., Rotter, A., Amato, D., Dringenberg, H.C., Mansor, S.M., Navaratnam, V., Müller, C.P. (2014) Abuse potential and adverse cognitive effects of mitragynine (Kratom). Addict Biol., 21 (1), 98-110.
  21. Annegowda, H.V., Bhat, R., Yeong, K.J., Liong M.T., Karim, A.A., Mansor, S.M. (2014) Influence of drying treatments on polyphenolic contents and antioxidant properties of raw and ripe papaya (Carica papaya L.) . International Journal of Food Properties, 17 (2), 283-292.
  22. Lee, M.J., Ramanathan, S., Ismail, R, Mansor, S.M., Ali, M.A., Tan, S.C. (2014) Stability test for the enzyme immunoassay reagents of Mitragynine. Asian Pacific Journal of Tropical Disease, 4 (3), 244.
  23. Goh, T.B., Yian, K.R., Mordi, M.N., Mansor, S.M. (2014) Antioxidant value and antiproliferative efficacy of mitragynine and a silane reduced analogue. Asian Pasific Journal of Cancer Prevention, 15 (14), 5659-5665.
  24. Goh, T.B., Meesala, R., Mordi, M.N., Mansor, S.M. (2014) Unexpected reduction of indole double bond in mitragynine using n-Butylsilane and catalytic tris (Pentaflorophenyl) borane. Synthetic Communications, 44 (9), 1291-1295.
  25. Kamilla, L.., Ramanathan, S., Sasidharan, S., Mansor, S.M. (2014) Evaluation of antinociceptive effect of methanolic leaf and root extracts of Clitoria ternatea Linn. in rats. Indian J Pharmacol., 46 (5), 515-520.
  26. Kamilla, L., Murugaiyah, V., Ramanathan, S., Sasidharan, S., Mansor, S.M. (2014) Efficacy of Clitoria ternatea leaf extract against experimental aspergillosis. International Journal of Pharmacy of Pharmaceutical Sciences, 6 (11), 514-516.
  27. Hazim, A.I., Ramanathan, S., Parthasarathy, S., Muzaimi, M., Mansor, S.M. (2014) Anxiolytic-like effects of mitragynine in the open-field and elevated plus-maze test in rats. J Physiol Sci., 64 (3), 161-169.
  28. Meesala, R., Mordi, M.N., Mansor, S.M., Rosli, M.M. (2014) Synthesis and crystal structure analysis of 9-Phenyl-β-carboline. Molecular Crystals and Liquid Crystals, 605 (1), 125-134.
  29. Meesala, R., Mordi, M.N., Mansor, S.M. (2014) Copper-catalyzed protodecarboxylation and aromatization of tetrahydro-β-carboline-3-carboxylic acids. Synlett, 25 (1), 120-122.
  30. Goh, T.B., Mordi M.N., Mansor, S.M. (2013) Demethylation of mitragynine picrate with BBr3 and C12H25-SH/NaOMe: A new entry for ester derivatives preparation based on position carbon 9. Asian J. Research Chem., 6 (9), 863-867.
  31. Purushotham, K.N., Annegowda H.V., Sathish N.K., Ramesh B., Mansor, S.M. (2013) Evaluation of phenolic and antioxidant potency in various parts of Cassia auriculata L.: A traditionally valued plant. Pak J Biol Sci., 17 (1), 41-48.
  32. Sabetghadam, A., Navaratnam, V., Mansor, S.M. (2013) Dose-response relationship, acute toxicity, and therapeutic index between the alkaloid extract of Mitragyna speciosa and its main active compound mitragynine in mice. Drug Development Research, 74 (1), 23-30.
  33. Aruldass, C.A., Marimuthu, M.M., Ramanathan, S., Mansor, S.M., Murugaiyah, V. (2013) Effects of Mesua ferrea leaf and fruit extracts on growth and morphology of Staphylococcus aureus. Microsc Microanal., 19 (1), 254-260.
  34. Parthasarathy, S., Ramanathan, S., Murugaiyah, V., Hamdan, M.R., Mohd Said, M.I., Lai, C.S., Mansor, S.M. (2013) A simple HPLC-DAD method for the detection and quantification of psychotropic mitragynine in Mitragyna speciosa (ketum) and its products for the application in forensic investigation. Forensic Sci Int., 226 (1-3), 183-187.
  35. Sabetghadam, A., Ramanathan, S., Sasidharan, S., Mansor, S.M. (2013) Subchronic exposure to mitragynine, the principal alkaloid of Mitragyna speciosa, in rats. J Ethnopharmacol., 146 (3), 815-823.
  36. Hassan, Z., Muzaimi, M., Navaratnam, V., Yusoff, N.M., Suhaimi, F.W., Vadivelu, R., Vicknasingam, B.K., Amato, D., von HÖrsten, S., Ismail, N.I., Jayabalan, N., Hazim, A.I., Mansor, S.M., Müller, C.P. (2013) From Kratom to mitragynine and its derivatives: Physiological and behavioural effect related to use, abuse and addiction. Neurosci Biobehav Rev., 37 (2), 138-151.
  37. Annegowda, H.V., Tan, P.Y., Mordi, M.N., Ramanathan, S., Hamdan, M.R., Sulaiman, M.H., Mansor, S.M. (2013) TLC-bioautography-guided isolation, HPTLC and GC-MS-assisted analysis of bioactive of Piper betle leaf extract obtained from various extraction techniques: In vitro evaluation of phenolic content, antioxidant and antimicrobial activities. Food Anal Methods, 6 (3), 715-726.
  38. Senik, M.H., Mansor, S.M., Rammes, G., Tharakan, J.K., Abdullah, J. (2012) Mitragyna speciosa Korth standardized methanol extract induced short-term potentiationof CA1 subfield in rat hippocampal slices. J. Med. Plant Res., 6 (7), 1234-1243.
  39. Lee, Y.K., Lay, L.K., Mansor, S.M., Guan, T.S., Elumalai, S., Thong, O.M. (2012) Anti-proliferation effect of Hevea brasiliensis latex B-serum on human breast epithelial cells. Pak J Pharm Sci., 25 (3), 645-650.
  40. Goh, T.B., Mordi, M.N., Mansor, S.M., Rosli, M.M., Fun, H.K. (2012) Bis(6-methoxy-1-methyl-2,3,4,9-tetra-hydro-1H-β-carbolin-2-ium) tetra-chloridozincate(II) dihydrate. Acta Crystallogr Sect E Struct Rep Online, 68 (4), m464-m465.
  41. Goh, T.B., Mordi, M.N., Mansor, S.M., Rosli, M.M., Fun, H.K. (2012) 6-methoxy-1-(4-methoxyphenyl)-1,2,3,4-tetrahydro-9H-β-carbolin-2-ium acetate. Acta Crystallogr Sect E Struct Rep Online, 68 (Pt 5), o1483.
  42. Anwar, R., Ismail, S., Mansor, S.M. (2012) In vitro effect of mitragynine on activity of drug metabolizing enzymes, n-demethylase and glutathione s-transferase in streptozotocin-induced diabetic rats. PharmacologyOnline, 1, 68-75.
  43. Annegowda, H.V., Bhat, R., Min-Tze, L., Karim, A.A., Mansor, S.M. (2012) Influence of sonication treatments and extraction solvents on the phenolics and antioxidants in star fruits. J Food Sci Technol., 49 (4), 510-514.
  44. Annegowda, H.V., Mordi, M.N., Ramanathan, S., Hamdan, M.R., Mansor, S.M. (2012) Effect of extraction techniques on phenolic content, antioxidant and antimicrobial activity of Bauhinia purpurea: HPTLC determination of antioxidants. Food Anal. Methods, 5 (2), 226-233.
  45. Annegowda, H.V., Gooi, T.S., Awang, S.H.H., Alias, N.A., Mordi, M.N., Ramanathan, S., Mansor, S.M. (2012) Evaluation of analgesic and antioxidant potency of various extracts of Cinnamomum iners bark. International Journal of Pharmacology, 8 (3), 198-203.
  46. Mohd Ali, N.I., Annegowda, H.V., Mansor, S.M., Ismail, S., Ramanathan, S., Mordi, M.N. (2012) Phytochemical screening, antioxidant and analgesic activities of Croton argyratus ethanolic extracts. Journal of Medicinal Plants Research, 6 (21), 3724-3731.
  47. Mohd Harizal Senik, Sharif Mahsufi Mansor, John Tharakan K.J., Jafri Malin Abdullah. (2012) Effect of acute administration of Mitragyna speciosa Korth standardized methanol extract in animal model of learning and memory. Journal of Medicinal Plants Research, 6 (6), 1007-1014.
  48. Rukhsana Anwar, Abas Hussin, Sabariah Ismail, Sharif Mahsufi Mansor. (2012) In vitro effect of mitragynine (a major alkaloid of Mitragyna speciosa Korth) on aminopyrine metabolism in rat hepatocytes. International Journal of Pharmaceutical Sciences and Research, 3 (7), 2238-2242.
  49. Mustaffa, F., Indurkar, J., Ismail, S., Shah, M., Mansor, S.M. (2011). An antimicrobial compound isolated from Cinnamomum iners leaves with activity against methicillin-resistant Staphylococcus aureus. Molecules, 16 (4), 3037-3047.
  50. Annegowda, H.V., Bhat, R., Tze, L.M., Karim, A.A., Mansor, S.M. (2011) The free radical scavenging and antioxidant activities of pod and seed extract of Clitoria fairchildiana (Howard) – an underutilized legume. J Food Sci Technol., 50 (3), 535-541.
  51. Sahgal, G., Ramanathan, S., Sasidharan, S., Mordi, M.N., Ismail, S., Mansor, S.M. (2011) In vitro and in vivo anticandidal activity of Swietenia mahogany methanolic seed extract. Trop Biomed., 28 (1), 132-137.
  52. Hamsar, M.N., Ismail, S., Mordi, M.N., Ramanathan, S., Mansor, S.M. (2011) Antioxidant activity and the effect of different parts of Areca catechu extracts on Glutathione-S-Transferase activity in vitro. Free Radicals and Antioxidants, 1 (1), 28-33.
  53. Hanapi, N.A., Azizi, J., Ismail, S., Mansor, S.M. (2010) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro. International Journal of Pharmacology, 6 (4), 494-499.
  54. Rajoo, A., Ramanthan, S., Sasidharan, S., Mansor, S.M. (2010) Standardization of Elaeis guineensis with respect to authenticity, assay and chemical constituent analysis. African Journal of Biotechnology, 9 (44), 7544-7549.
  55. Mustaffa, F., Indurkar, J., Ismail, S., Mordi, M.N., Ramanathan, S., Mansor, S.M. (2010) Antioxidant capacity and toxicity screening of Cinnomomum iners standardized leaves methanolic extract. International Journal of Pharmacology, 6 (6), 888-895.
  56. Annegowda, H.V., Anwar, L.N., Mordi, M.N., Ramanathan, S., Mansor, S.M. (2010) Influence of sonication on phenolic content and antioxidant activity of Terminalia catappa L. leaves. Pharmacognosy Res., 2 (6), 368-373.
  57. Annegowda, H.V., Ween Nee, C., Mordi, M.N., Ramanathan, S., Mansor, S.M. (2010) Evaluation of phenolic content and antioxidant property of hydrolysed extract of Terminalia catappa L. leaf. Asian Journal of Plant Sciences, 9 (8), 479-485.
  58. Annegowda, H.V., Ween Nee, C., Mordi, M.N., Ramanathan, S., Mansor, S.M. (2010) Analgesic and antioxidant properties of ethanolic extract of Terminalia catappa L. leaves. International Journal of Pharmacology, 6 (6), 910-915.
  59. Harizal, S.N., Mansor, S.M., Hasnan, J., Thakaran, J.K.J., Abdullah, J. (2010) Acute toxicity study of the standardized methanolic extract of Mitragyna speciosa Korth in rodent. J Ethnopharmacol., 131 (2), 404-409.
  60. Sahgal, G., Ramanathan, S., Sasidharan, S., Mordi, M.N., Ismail, S., Mansor, S.M. (2010) Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni  (Linn.) Jacq. seed methanolic extract. Pharmacognosy Res., 2 (4), 215-220.
  61. Sabetghadam, A.,  Ramanathan, S., Mansor, S.M. (2010) The evaluation of antinociceptive activity of alkaloid, methanolic, and aqueous extract of Malaysian Mitragyna speciosa Korth leaves in rats. Pharmacology Res., 2 (3), 181-185.
  62. Mustaffa, F., Indurkar, J., Ismail, S., Mordi, M.N., Ramanathan, S., Mansor, S.M. (2010) Analgesic activity, toxicity study and phytochemical screening of standardized Cinnomomum iners leaves methanolic extract. Pharmacognosy Res., 2 (2), 76-81.
  63. Venkatesh, G., Majid, M.I.A., Mansor, S.M., Nair, N.K., Croft, S.L., Navaratnam, V. (2010) In vitro and in vivo evaluation of self-microemulsifying drug delivery system of buparvaquone. Drug Dev Ind Pharm., 36 (6), 735-743.
  64. Al-Azzam, K.M., Makahleah, A., Saad, B., Mansor, S.M. (2010) Hollow fiber liquid-phase microextraction for the determination of trace amounts of rosiglitazone (anti-diabetic drug) in biological fluids using capillary electrophoresis and high performance liquid chromatography methods. J Chromatogr A., 1217 (23), 3654-3659.
  65. Vicknasingam, B., Narayanan, S., Beng G.T., Mansor, S.M. (2010) The informal use of ketum (Mitragyna speciosa) for opioid withdrawal in the northen state of peninsular Malaysia and implications for drug substitution therapy. Int J Drug Policy, 21 (4), 283-288.
  66. Parthasarathy, S., Ramanathan, S., Ismail, S., Adenan, M.I., Mansor, S.M., Murugaiyah, V. (2010) Determination of mitragynine in plasma with solid-phase extraction and rapid HPLC-UV analysis, and its application to a pharmacokinetic study in rat. Anal Bioanal Chem., 397 (5), 2023-2030.
  67. Krishnan, N., Ramanathan, S., Sasidharan, S., Murugaiyah, V., Mansor, S.M. (2010) Antimicrobial activity evaluation of Cassia spectabilis leaf extracts. International Journal of Pharmacology, 6 (4), 506-510.
  68. Azizi, J., Ismail, S., Mordi, M.N., Ramanathan, S., Said, M.I., Mansor, S.M. (2010) In vitro and in vivo effect of three different Mitragyna speciosa Korth leaves extracts on phase II drug metabolizing enzymes-glutathione transferases (GSTs). Molecules, 15 (1), 432-441.