Upon being designated as one of the Higher Institution Centre of Excellence (HICoE) by the Ministry of Higher Education Malaysia, CDR has expanded its research focus by establishing new laboratories to facilitate behavioural neuroscience research using animal models. The researchers strive to understand the neural mechanisms of motivation, learning and memory particularly in drug addiction and neurodegenerative disease. Measurement of dynamic changes in extracellular levels of neurotransmitter using in vivo microdialysis technique enables correlation between behavioural changes and neurochemical events be made. Measurement of brain activity (EEG) and synaptic plasticity in vivo are also areas of expertise at CDR.
Blood-Brain Barrier Research
CDR pioneering research in blood-brain barrier (BBB) in Malaysia. The BBB formed by brain capillary endothelium which helps regulate microenvironment of the brain is an important area of research in drug discovery and development, and in also in neurodegenerative disease studies. At CDR, we are interested to look at transport mechanisms across the BBB and how the BBB function is altered in pathological condition.