Dr. Zurina Hassan
DR. ZURINA HASSAN
The behavioural neuroscience was founded in October 2010 at the Centre for Drug Research (CDR), Universiti Sains Malaysia, Penang, Malaysia. We were given the mandate to establish a new behavioural neuroscience lab at this centre. We are the pioneer in this institution and embarked on a new niche area of research focusing on Behaviour Research in Addiction. We emphasize on behaviour neuroscience and striving to be a reference centre for those who are planning to participate in behaviour neuroscience in their research. Our concern is to understand the neural mechanisms of motivation, learning and memory especially in drug addiction and neurodegenerative disease. We have developed the Electrophysiology Lab focusing on brain activity (EEG) and in vivo synaptic plasticity. A technique known as in vivo microdialysis is developed at CDR to measure the dynamic changes on extracellular levels of neurotransmitters in the specific brain sites. Using this method, information on the correlations between the behavioural effects and neurochemical events could be possibly addressed. Examination on the involvement of systemic opioid, GABA, noradrenergic, dopaminergic and serotonergic system on these addictive behaviours enable comprehensive understanding of how brain mechanisms regulate these complex behaviours.
Current Research Projects:
- Role of dopamine and its reflection in spectral frequencies of EEG in freely moving addictive rats
- Behavioural research in addiction
- Effects of psychoactive drugs on changes in spontaneous electroencephalographic (EEG) and behavioral activities in addictive animal models
- Neural mechanism of mitragynine (a major indole alkaloid of Mitragyna speciosa) rewarding properties and neurochemical events in several discrete brain areas: potential treatment of opiate addiction
- Evaluation of addiction severity and withdrawal effect in mitragynine treated rats
- Neuroplasticity and role of cholinergic system in cognitive behaviour
- Brain activity (EEG) and synaptic plasticity in chronic cerebral ischemia model
- Neuroprotective effects of standardized Clitorea ternatea root extract for the treatment of memory disorders and improving cognitive behaviour in chronic cerebral ischemia model
- Evaluations of neuroprotective activity of standardized ethanolic Orthosiphon stamineus extract to ameliorate cognitive alterations in Alzheimer's disease
Current PhD students (as main supervisor)
- Nurul Hasnida Mohammad Yusof
- Thenmoly A/P K Damodaran
- Nurul Aqmar Mohamad Nor Hazalin
- Rahimah Hassan
Current MSc student (as main supervisor)
- Nor Fasihah Azam
SELECTED PUBLICATIONS (FROM 2010)
- Yusoff, N.H.M., Mansor, S.M., Müller, C.P., Hassan, Z. (2017) Opioid receptors mediate the acquisition, but not the expression of mitragynine-induced conditioned place preference in rats. Behav Brain Res., 332, 1-6.
- Müller, C.P., Hassan, Z. (2016) The evaluation of new psychoactive drugs. Brain Res Bull., 126 (Pt 1), 1-2.
- Suhaimi, F.W., Yusoff, N.H., Hassan, R., Mansor, S.M., Navaratnam, V., Müller, C.P., Hassan, Z. (2016) Neurobiology of Kratom and its main alkaloid mitragynine. Brain Res Bull., 126 (Pt 1), 29-40.
- Yusoff, N.H., Suhaimi, F.W., Vadivelu, R.K. , Hassan, Z., Rümler, A., Rotter, A., Amato, D., Dringenberg, H.C., Mansor, S.M., Navaratnam, V., Müller, C.P. (2016). Abuse potential and adverse cognitive effects of mitragynine (kratom). Addiction Biology, 21 (1), 98-110.
- Mustaffa, F., Hassan, Z., Asmawi, M.Z. (2016). Cinnamomum iners leaves as an alternative therapy for diabetes. Asian Journal of Biochemistry, 11 (1), 44-52.
- Mustaffa, F., Hassan, Z., Asmawi, M.Z. (2016). Antioxidant activity of Cinnamomum iners leaves standardized extract. Asian Journal of Biochemistry, 11 (2), 90-96.
- Harun, N., Hassan, Z., Navaratnam, V., Mansor, S.M., Shoaib, M. (2015) Discriminative stimulus properties of mitragynine (Kratom) in rats. Psychopharmacology (Berl), 232 (13), 2227-2238.
- Harun, N., Hassan, Z., Navaratnam, V., Mansor, S.M., Shoaib, M. (2014) Discriminative stimulus properties of mitragynine, an alkaloid derived from leaves Mitragyna speciosa (Kratom). Journal of Psychopharmacology, 28 (8), A88.
- Mustaffa, F., Hassan, Z., Yusof, N.A., Razak, K.N.A., Asmawi, M.Z. (2014) Bioassay-guided antidiabetic mechanisms of Cinnamomum iners leaves extract. World Journal of Pharmaceutical Research, 3 (6), 1924-1935.
- Damodaran, T., Hassan, Z., Navaratnam, V., Muzaimi, M., Ng, G., Müller, C.P., Liao, P., Dringenberg H.C. (2014) Time course of motor and cognitive functions after chronic cerebral ischemia in rats. Behav Brain Res., 275, 252-258.
- Kura, A.U., Cheah, P.S., Hussein, M.Z., Hassan, Z., Tengku Azmi, T.I., Hussein, N.F., Fakurazi, S. (2014) Toxicity evaluation of zinc aluminium levodopa nanocomposite via oral route in repeated dose study. Nanoscale Res Lett., 9 (1), 261.
- Mustaffa, F., Hassan, Z., Yusof, N.A., Abdul Razak, K.N., Asmawi, M.Z. (2014) Antidiabetic and antihyperlipidemic potential of standardized extract, fraction and subfraction of Cinnamomum iners Leaves. International Journal of Pharmacy and Pharmaceutical Sciences, 6 (5), 220-225.
- Mustaffa, F., Hassan, Z., Yusof, N.A., Abdul Razak, K.N., Asmawi, M.Z. (2014) Antidiabetic mechanism of standardized extract, fraction and subfraction of Cinnamomum iners leaves. Int. J. Pharm. Sci. Rev. Res., 26 (2), 209-214.
- Manshor, N.M., Dewa, A., Asmawi, M.Z., Ismail, Z., Razali, N., Hassan, Z. (2013) Vascular reactivity concerning Orthosiphon stamineus Benth-mediated antihypertensive in aortic rings of spontaneous hypertensive rats. International Journal of Vascular Medicine, Article ID 456852.
- Hassan, Z., Sattar, M.Z., Suhaimi, F.W., Yusoff, N.H., Abdulla, M.H., Yusof, A.P., Johns, E.J. (2013) Blunted endogenous GABA-mediated inhibition in the hypothalamic paraventricular nucleus of rats with streptozotocin-induced diabetes. Acta Neurol Belg., 113 (3), 319-325.
- Razali, N., Dewa, A., Asmawi, M.Z., Ismail, Z., Mansor, N.M., Hassan, Z. (2013) Vascular reactivity on aortic rings of spontaneously hypertensive rats treated with methanolic and water extracts of Ficus deltoidea. J Exp Integr Med., 3 (2), 93-102.
- Hassan, Z., Muzaimi, M., Navaratnam, V., Yusoff, N.H., Suhaimi, F.W., Vadivelu, R., Vicknasingam, B.K., Amato, D., von HÖrsten, S., Ismail, N.I., Jayabalan, N., Hazim, A.I., Mansor, S.M., Müller, C.P. (2013) From kratom to mitragynine and its derivatives: physiological and behavioral effects related to use, abuse, and addiction. Neurosci Biobehav Rev., 37 (2), 138-151.
- Hassan, Z., Dewa, A., Asmawi, M.Z., Sattar, M.Z. (2011) Assessment of vascular reactivity at different time-course on STZ-induced diabetic rats. J Exp Integr Med., 1 (3), 175-183.
- Hassan, Z., Yam, M.F., Ahmad, M., Yusof, A.P. (2010) Antidiabetic properties and mechanism of action of Gynura procumbens water extract in streptozotocin-induced diabetic rat. Molecules, 15 (12), 9008-9023.
- Nor Fasihah Azam, Zurina Hassan, Hans C. Dringenberg (2014) The effect of permanent occlusion of common carotid arteries on electroencephalogram (EEG) in rat’s brain. Archives of Pharmacy Practice, 5 (Supplement 1), S9.
- Hasnida, N., Yusoff, M., Hassan, Z., Visweswaran, N., Müller C.P. (2013) Simultaneous monitoring of conditioned place preference and locomotor sensitization in mitragynine-treated rats. Behavioural Pharmacology, 24 (e-Supplement Abstract of the 15th Biennial Meeting of the European behavioural Pharmacology Society, La Rochelle, September 6-9, 2013) e58, October 2013.
- Mohammad Yusoff, N., Hassan, Z., Navaratnam, V., Müller, C.P. (2012) Effects of acute mitragynine exposure on the establishment of conditioned place preference and locomotor activity. Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference. doi: 10.3389/conf.fnhum.2012.208.00118.
- Hassan, Z., Sofian, Z.M., Navaratnam, V. (2012) Changes in the spontaneous EEG and locomotor activity of freely moving rats in mitragynine-treated animals. Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference. doi: 10.3389/conf.fnhum.2012.208.00042.
- Suhaimi, F., Hassan, Z., Navaratnam, V., Müller C.P. (2012) Impairment of memory formation, consolidation and retrieval of inhibitory avoidance task in acute mitragynine-treated rats. Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference. doi: 10.3389/conf.fnhum.2012.208.00176.